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专业、专心、专注 聚乳酸材料研发

济南岱罡生物工程有限公司 Jinan Daigang Co., Ltd

 
 
 

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济南岱罡生物工程有限公司专业从事医用生物降解材料的研究和制品开发。 产品有单体:丙交酯(LA)、乙交酯(GA)、三亚甲基碳酸酯(TMC)、对二氧环己酮(PDO),聚合物:聚乳酸、聚乙醇酸、聚酸酐、聚三亚甲基碳酸酯、聚对二氧环己酮以及共聚物,制品:静电纺丝膜、生物降解纤维、多孔泡沫支架。可以根据用户要求进行特殊结构聚乳酸类衍生物的合成

网易考拉推荐

聚乳酸及其共聚物的物性和降解  

2008-12-17 23:29:59|  分类: 默认分类 |  标签: |举报 |字号 订阅

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Polymer

Inherent Viscosity(dL/g)

Crystalline Melt Transition(°C)

GlassTransition
Temp (°C)

Approx. Resorption
(months)

DL-PLGA50/50

0.05-0.15

Amorphous

45-50

1-2(周)

DL-PLGA50/50

0.15-0.25

Amorphous

45-50

2-4(周)

DL-PLGA50/50

0.25-0.55

Amorphous

45-50

3-4(周)

DL-PLGA50/50

0.55-0.75

Amorphous

45-50

1-2

DL-PLGA65/35

0.55-0.75

Amorphous

45-50

3-4

DL-PLGA75/25

0.55-0.75

Amorphous

50-55

4-5

DL-PLGA85/15

0.55-0.75

Amorphous

50-55

5-6

DL-PLA

0.55-0.75

Amorphous

50-60

12-16

L-PLA

0.9-1.2

175-185

60-65

>24

PGA

1.4-1.8

225-230

35-40

6-12

PCL

1.0-1.3

58-63

-65-60

>24

DL Lactide/ Glycolide Mole Ratio Inherent Viscosity (dL/g) Degradation Time frame

100 DL 7E    0.60 - 0.80    100 / 0      12 - 16 months

Previous Name: 100 DL High IV

Appearance: White to yellow pellets

Inherent Viscosity: 0.60 - .80 dL/g

Residual Monomer: 2.0% maximum

Tin Content: 200 ppm maximum

End Group: Ester

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

8515 DLG 7E     0.60 - 0.80     85 / 15    5 - 6 months

Previous Name: 8515 DL High IV

Appearance: White to yellow pellets

Inherent Viscosity: 0.60 - .80 dL/g

Copolymer Mole Ratio

  d,l-lactide 80-90% Mole

  glycolide 10-20% Mole

Residual Monomer: 2.0% maximum

  % d,l-lactide Report Result

  % glycolide Report Result

Tin Content: 200 ppm maximum

End Group: Ester

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

7525 DLG 7E 0.60 - 0.80 75 / 25 4 - 5 months

Previous Name: 7525 DL High IV

Appearance: White to yellow pellets

Inherent Viscosity: 0.60 - .80 dL/g

Copolymer Mole Ratio

  d,l-lactide 70 - 80% Mole

  glycolide 20 - 30% Mole

Residual Monomer: 2.0% maximum

  % d,l-lactide Report Result

  % glycolide Report Result

Tin Content: 200 ppm maximum

End Group: Ester

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

6535 DLG 7E 0.60 - 0.80 65 / 35 3 - 4 months

Previous Name: 6535 DL High IV

Appearance: White to yellow pellets

Inherent Viscosity: 0.60 - .80 dL/g

Copolymer Mole Ratio

  d,l-lactide 60 - 70% Mole

  glycolide 30 - 40% Mole

Residual Monomer: 2.0% maximum

  % d,l-lactide Report Result

  % glycolide Report Result

Tin Content: 200 ppm maximum

End Group: Ester

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

5050 DLG 7E 0.60 - 0.80 50 / 50 1 - 2 months

Appearance: White to yellow pellets

Inherent Viscosity: 0.60 - .80 dL/g

Copolymer Mole Ratio

  d,l-lactide 45 - 55% Mole

  glycolide 45 - 55% Mole

Residual Monomer: 2.0% maximum

  % d,l-lactide Report Result

  % glycolide Report Result

Tin Content: 200 ppm maximum

End Group: Ester

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

5050 DLG 5E*** 0.45 - 0.55 50 / 50 1 - 2 months

Previous Name: 5050 DL High IV***

Appearance: White to off-white granular powder

Inherent Viscosity: 0.45 - .55 dL/g

Copolymer Mole Ratio

  d,l-lactide 45 - 55% Mole

  glycolide 45 - 55% Mole

Residual Monomer: 2.0% maximum

  % d,l-lactide Report Result

  % glycolide Report Result

Tin Content: 200 ppm maximum

End Group: Ester

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

5050 DLG 1A 0.05 - 0.15 50 / 50 1 - 2 weeks

Previous Name: 5050 DL 1A

Appearance: White to off-white granular powder

Inherent Viscosity: 0.05 - .15 dL/g

Copolymer Mole Ratio

  d,l-lactide 46 - 52% Mole

  glycolide 48 - 54% Mole

Residual Monomer:

  % d,l-lactide 1.2% max

  % glycolide 0.3% max

Tin Content: 200 ppm maximum

End Group: Acid

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

5050 DLG 2A 0.15 - 0.25 50 / 50 2 - 4 weeks

Previous Name: 5050 DL 2A

Appearance: White to off-white granular powder

Inherent Viscosity: 0.15 - .25 dL/g

Copolymer Mole Ratio

  d,l-lactide 50 - 54% Mole

  glycolide 46 - 50% Mole

Residual Monomer:

  % d,l-lactide 1.2% max

  % glycolide 0.3% max

Tin Content: 200 ppm maximum

End Group: Acid

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

5050 DLG 3A 0.25 - 0.35 50 / 50 3 - 4 weeks

Previous Name: 5050 DL 3A

Appearance: White to off-white granular powder

Inherent Viscosity: 0.25 - .35 dL/g

Copolymer Mole Ratio

  d,l-lactide 45 - 55% Mole

  glycolide 45 - 55% Mole

Residual Monomer:

  % d,l-lactide 1.2% max

  % glycolide 0.3% max

Tin Content: 200 ppm maximum

End Group: Acid

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

5050 DLG 4A 0.35 - 0.45 50 / 50 3 - 4 weeks

Previous Name: 5050 DL 4A

Appearance: White to off-white granular powder

Inherent Viscosity: 0.35 - .45 dL/g

Copolymer Mole Ratio

  d,l-lactide 45 - 55% Mole

  glycolide 45 - 55% Mole

Residual Monomer:

  % d,l-lactide 1.2% max

  % glycolide 0.3% max

Tin Content: 200 ppm maximum

End Group: Acid

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

5050 DLG 4.5A 0.40 - 0.50 50 / 50 3 - 4 weeks

Appearance: White to off-white granular powder

Inherent Viscosity: 0.40 - .50 dL/g

Copolymer Mole Ratio

  d,l-lactide 45-55% Mole

  glycolide 45-55% Mole

Residual Monomer:

  % d,l-lactide 1.2% max

  % glycolide 0.3% max

Tin Content: 200 ppm maximum

End Group: Acid

Molecular Weight, Mw: Report Mw, Mn and Polydispersity

Biodegradation kinetics vary from weeks to years depending upon numerous factors such as device geometry,porosity, monomer ratio, molecular weight, inherent viscosity, polymer end group, crystalline vs. amorphouscharacter. Due to these and many other factors, the degradation information provided should be used asa general guideline.
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